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Special Scenarios Post-COVID generalized weakness Documentation must be separate: active infection vs post-infectious recovery Objective strength deficits functional impairment and safety concerns structured plan with measured progress Weakness in older adults Older patients require clear separation between: generalized weakness (M62.81) confirmed sarcopenia (M62.84) Neurologic causes of weakness when present Fall risk documentation strengthens medical necessity when accurate and specific

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Tofacitinib, an inhibitor of inflammatory enzymes associated with RA, has recently been reported to prevent cytokine-induced gut barrier dysfunction as well as limiting the delocalisation of TJ proteins, such as ZO-1, in IECs following exposure to IFN- (Sayoc-Becerra et al