The peptide was originally characterized by the Sikiric group at the University of Zagreb School of Medicine and has been investigated for over two decades in preclinical research models for its effects on tissue regeneration, angiogenesis, fibroblast migration, and cellular signaling across tendon, ligament, muscle, gastrointestinal, and vascular tissues
Oral (Capsules or Powder): May be better for digestive tract research due to peptide stability in gastric juice
Circulating MOTS-c is detectable in humans and declines with age, but no completed human trial of administered MOTS-c has read out
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