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One group claiming that melittin has certain anti-inflammatory effects has provided interesting evidence of an influx of cytokines and nitric oxide caused by bee venom, which have been postulated to play important roles in mediating the cell recruitment and activation necessary to balance inflammation/anti-inflammation and repair tissue damage [79]

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This mechanistic insight provides a new biological framework for understanding the cardiorenal benefits of SGLT2 inhibitors and supports the development of ferroptosis-oriented therapeutic strategies for DKD