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The Aspen Clinic also provides its patients with guidance and support once your goal weight is reached, and we have specific maintenance protocols for GLP-1 users to get off the medication safely, without experiencing weigh gain

22 Insulin signaling pathways Physiologically, insulin binds to the extracellular subunit of insulin receptor, a receptor tyrosine kinase which recruits and phosphorates insulin receptor substrate (IRS)-1, thus activating phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling and diverse downstream pathways to maintain the glucose homeostasis

doi: 10.1093/toxsci/kfq364

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