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Weight regain can occur, which is why long-term habits, muscle preservation, and a maintenance plan are important

Scientists conducted a big study called the STEP (Semaglutide Treatment Effect in People with obesity) clinical trials to see if semaglutide could really help people lose weight and keep it off

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Phentermine, in particular, carries a well-documented side effect profile that includes: Cardiovascular effects : elevated heart rate, increased blood pressure, and palpitations Central nervous system effects : insomnia, anxiety, restlessness, and dizziness Gastrointestinal symptoms : dry mouth, nausea, and constipation Dependence and withdrawal : phentermine has stimulant properties and carries a risk of psychological dependence with prolonged use Phentermine and related sympathomimetic agents are contraindicated in people with uncontrolled hypertension, ischaemic heart disease, arrhythmias, hyperthyroidism, glaucoma, or a history of drug or alcohol misuse