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Following wrist injury, administering vitamin C as a daily dose from 200 to 1500 g in a period of up to 50 days reduced the risk of CRPS and consequently was approved as a prophylactic treatment of CRPS [54]

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This manifested as an increase of intracellular ROS and a marked decrease of GSH

S(CAM-TPP ) 2 , dichloride salt A solution of 5-aminopentyltriphenylphosphonium bromide hydrogen bromide 58 (200 mg, 0.4 mmol), 2,2-thiodiacetic acid (S(CAM) 2 30 mg, 0.2 mmol), HBTU (182 mg, 0.48 mmol) and DIPEA (0.14 mL, 0.8 mmol) in anhydrous DMF (2.0 mL) was stirred under argon for 1 h