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USP2 WT transfection promoted TGF1-induced nuclear localization of SMAD3, and increased SMAD3-mediated transcriptional activity, the protein level of TGFBR1 , and the mRNA level of TGF signaling target genes ( COL1A1, COL1A2, SERPINE1 , and SMAD7 ), while USP2 K447R abolished these effects (Fig

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Microglia-triggered plasticity of intrinsic excitability modulates psychomotor behaviors in acute cerebellar inflammation

For instance, the EPA has proposed maximum contaminant levels of 4 parts per trillion for PFOA and PFOS in drinking water, reflecting the understanding that even minute quantities can have significant health impacts