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Risks include: reduced eGFR long-term kidney impairment progression of chronic kidney disease recurrent acute kidney injury (AKI) increased dialysis risk in vulnerable patients Related: Ozempic Kidney Problems Gallbladder Disease Rapid weight loss common with GLP-1 drugs is a major risk factor for gallbladder issues

The 72-hour minimum gap between any two injections prevents plasma drug levels from stacking to supratherapeutic concentrations, which increases the risk of GI adverse events (nausea, vomiting, diarrhea) that are already the most common reason patients discontinue GLP-1 therapy

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5 The bioactive forms, GLP-1(737) and most abundantly, GLP-1(736)NH 2 , are inactivated by dipeptidyl peptidase-4 (DPP-4)