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Protein kinase inhibitors: structural insights into selectivity

Getting this wrong can easily derail an entire study

The high cost, stringent regulatory oversight, and decades involved in the execution of rigorous clinical trials create barriers for advancement of this technology

Recently, different in vitro and in vivo studies reported sepsis-induced changes in the shape of human erythrocytes, which have also been confirmed in animal models and humans [126, 381,382,383,384,385,386,387,388,389]