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In terms of efficacy, after 24 weeks of treatment, the changes in body weight for different doses in the Retatrutide group were: -2.1% for the placebo group, -7.2% for the 1 mg group, -12.9% for the 4 mg group, -17.3% for the 8 mg group, and -17.5% for the 12 mg group

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GLP-1 is secreted in response to nutrient ingestion leading to various effects on the body such as increased insulin secretion, decreased glucagon secretion, regulating proximal gut transit, and suppression of appetite signaling in the brain