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Xu H, Perez-Cuevas R, Xiong X, Reyes H, Roy C, Julien P, Smith G, von Dadelszen P, Leduc L, Audibert F, et al: An international trial of antioxidants in the prevention of preeclampsia (INTAPP)

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For maximum benefit : Many practitioners recommend combining subcutaneous injection (for systemic effects) with topical application (for skin-specific benefits)