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Description

In therapeutic dosage, paracetamol is largely metabolised by phase II processes (glucuronidation and sulphation) to stable metabolites, but between 5% and 10% also undergoes P450 metabolism to the toxic N -acetyl p-benzoquinoneimine (NAPQI) metabolite (Nelson, 1990) (Figure 8.3)

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c , The mechanisms of the biocatalytically competent amide bond synthetase McbA and the ATP-grasp enzyme TabS

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