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For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

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Unlike GHRPs, which worked indirectly through growth hormone, GLP-1 peptides directly target the metabolic pathways that control fat storage, appetite, and body composition