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Therefore, despite being only a partial effector of carcinogenesis, CBS belongs to a panel of intervening players, including NF-B, KRAS, p53 and Wnt components, that contribute to metabolic rewiring and increased proliferative and invasive potential

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Neither dose showed a statistically significant difference from placebo on the primary outcome of colonic transit time or on any of the secondary outcomes.[7] The strain still has a positive evidence base in the broader literature, but the largest single trial in functional constipation was null

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