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Oxidative stress occurs when there are too many damaging free radicals in the body compared to beneficial antioxidants, meaning the body cannot neutralize them
Oral dosing keeps plasma ascorbate below roughly 220 micromoles per liter (mol/L), whereas controlled IV infusion can safely **generate** pharmacologic concentrations of 2530 millimoles per liter (mmol/L)a finding documented by Mark Levines National Institutes of Health group in Vitamin C pharmacokinetics: implications for oral and intravenous use (Padayatty and colleagues, Annals of Internal Medicine, 2004)
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10.3389/fneur.2017.00342 270 ZhengK.HuF.ZhouY.ZhangJ.ZhengJ.LaiC.et al
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