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It is an FDA-approved drug for the management of hyperglycemia specifically in type 2 diabetes mellitus

Although current evidence is encouraging, further research is needed to confirm long-term outcomes

Lee noted: "As we age, that communication network seems to break down, but our study suggests you can restore that network or rejuvenate an older mouse so it is as fit as a younger one." A December 2024 study from Shanghai University of Sport tested serum MOTS-c levels in marathon runners versus sedentary subjects, finding a close association between circulating MOTS-c and aerobic exercise capacity

This meets the USP requirement of 0.5%