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Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

In late 2023, researchers published the results of the Phase III SELECT trial that investigated the use of semaglutide in patients with overweight and a previous history of cardiovascular disease but no diagnosis of diabetes

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doi: 10.3389/fmolb.2015.00050 Received 19 December 2014 Accepted 19 August 2015 Published 03 September 2015 Volume 2 - 2015 Edited by Laszlo Otvos, OLPE LLC, USA Reviewed by Anja Kunze, University of California, Los Angeles, USA