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According to a 2023 study[1] published in the journal, Dermatology Online , There are a number of reports on the onset of acute annular pustular psoriasis with the COVID-19 vaccine as well the development of pustular psoriasis in a patient with established plaque psoriasis following the administration of the vaccine It has been suggested that certain cutaneous COVID-19 vaccine reactions may represent unmasking of subclinical inflammatory dermatoses due to the immune boosting properties of the vaccine

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Inositol is a carbohydrate-related co-factor and choline is a phospholipid precursor, so the blend spans three different compound classes