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This effect may result from the promotion of healthy blood flow and oxygen supply to muscles along with the support of cellular metabolism [9].* Exercise is associated with an increased production of ROS that can promote tissue changes that support muscle adaptation to exercise, but that can also contribute to muscle damage and soreness [1012]

Tumor angiogenesis often results in a low-pH and hypoxic TME, which eventually limits drug efficacy

The peroxisome proliferator-activated receptor: a family of nuclear receptors role in various diseases