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2013;8(1):e54895

Xu S, Flanagan JL, Simmons PA, Vehige J, Willcox MD, Garrett Q

First, although we identified and validated PPAR as a key target through bioinformatics and experimentation, we did not perform knockdown or overexpression studies in cell lines to directly confirm a causal relationship between PPAR activity and inhibition of chondrocyte ferroptosis