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These modifications reduce binding to IGF binding proteins substantially, extending the half-life while maintaining receptor activation
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice
Association between genetic polymorphisms of glutathioneS-transferase P1 N-acetyltransferase 2 susceptibility to squamous-cell carcinoma of the esophagus
The failure of broader or less specific agents, therefore, reinforces the central theme that therapeutic success in MIRI demands a highly targeted approach that addresses the specific downstream consequences of the initial oxidative insult
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