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Following induction by LPS, CBD attenuated IL-8 and MCP-1 production but at the basal level, CBD induced the production of IL-8, CXCL1, Serpin E1, IL-6, IFN-y, MCP-1, RANTES, and TNF-, indicating that the effects of CBD may depend on the activation state [118] or anatomical location of the cells

This drives a continuous cycle of fat storage to protect against the physical stress of exhaustion

Once confirmed or diagnosed, no treatment is needed unless a biopsy is indicated because of changes or if there is a question regarding the etiology of the macule

There is no direct, targeted mechanism hitting the fat cells themselves the way AOD 9604 dosing protocols achieve through beta-3 receptor activation