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Direct effects on the sinoatrial node or cardiac tissue may also play a role, as GLP-1 receptors have been identified in cardiac tissue

While earlier GLP-1 drugs have decades of data behind them, newer high-potency agonists and multi-agonist combinations will require extended monitoring as their use expands

Siamashvili M, Davis SN (2021) Update on the effects of GLP-1 receptor agonists for the treatment of polycystic ovary syndrome