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Clinical Trial Dosing Ranges Dose Titration Schedules Clinical trials have employed gradual dose escalation to minimize gastrointestinal side effects [9] : Standard Titration Protocol (Example from ONWARDS 1) Rationale: Gradual titration allows tolerance development to gastrointestinal effects (particularly nausea) while building up to therapeutic doses

It exhibits an IC 50 of approximately 1 M for NNMT inhibition 4 , with favorable pharmacokinetic properties

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At a median of 75-month follow-up, patients demonstrated markedly improved Knee Society pain and function scores and decreased pain compared with preoperative scores