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Since 2006, glucagon-like peptide-1 receptor (GLP-1R) agonists have caused a dramatic change in the treatment of type 2 diabetes, with clinically relevant and sustained effects on glycaemic control and body weight combined with cardioprotective mechanisms [3, 4]

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Relamorelin, a ghrelin agonist, led to both symptomatic improvement and acceleration of gastric emptying in three studies, but the subsequent phase 3 trial was terminated prematurely, apparently for commercial reasons [79]