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The authors suggested that given previous research that formononetin displays slower glucuronidation in intestinal and hepatic microsomes and higher gut permeability [127], formononetin bioavailability have benefited from its structural methylation status making it more liposoluble and improving permeability [126]
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Lee KK, Imaizumi N, Chamberland SR, Alder NN, Boelsterli UA (2015) Targeting mitochondria with methylene blue protects mice against acetaminophen-induced liver injury
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